According to WHO 2020, there are about 48 million infertility couples in the world currently. In recent years, assisted reproductive technology has been developed strongly and achieved significant milestones. According to Koot 2012, however, there are still about 8-10% of couples with recurrent implantation failure (RIF). One of the reasons, even with the good quality embryo or an euploid embryo transfer, is the abnormal endometrium or related to the implantation window. Thus, it is necessary to use molecular diagnostic tests including ERA, EMMA and ALICE to provide information on the implantation window of the endometrium, microbiome profile and chronic endometritis. At the ART Center of Tam Anh General Hospital in Hanoi, Vietnam, we have applied this trio-tests to patients who have RIF. From March 2020 to February 2022, 17 patients with recurrent implant failures were concurrently tested for ERA, EMMA and ALICE. In 13 patients had embryo transfer after the test, 6 patients got pregnant, in which 1 patient had five previous failures. This is a promising result, opening up hope for patients with RIF. However, the advantage of these tests needs more evidence to confirm.
Graduating from Hanoi Medicine University in Obstetric Surgery in 1990, Assoc. Prof. Le Hoang worked at the National Hospital of Obstetrics and Gynecology (NHOG). In 1998, he was one of the first Northern doctors sent to Thailand to learn IVF techniques. He took a Gynecology and Obstetric intern course in France between 2001 and 2002. From 2011 to 2017, he was the Vice Director of the ART Center of NHOG and became the Vice Director of NHOG from 2013 to 2017.
He has been the Director of the ART Center, Tam Anh General Hospital, since 2017 until now. He is also the Vice President of Ha Noi ART Association, the honorary member of the French College of Obstetricians and Gynecologist (CNGOF), a member of the Executive Committee of Vietnam Association of Obstetricians and Gynecologist, Secretary of Vietnam Society for Reproductive Medicine, and the member of American Society of Reproductive Medicine.
- First author: Pregnancy Outcomes Following the First Frozen Blastocyst Transfer Among Women Aged Less Than 35 Years Old: A Retrospective Cohort Study, Fertility & Reproduction. 2021; Vol. 03, No. 04, pp. 143-149
- Co-author: Erectile Dysfunction and Infertility: A Pilot Study in Male Partners of Infertile Couples, Nephro-Urology Monthly. 2021; 13(3):e112638.
- First author: Comparative Effectiveness of Mild or Conventional GnRH-Antagonist Protocols for Ovarian Stimulation in Poor Responders (Poseidon Group 4), Frontiers in Reproductive Health. 2020; doi: 10.3389/frph.2020.606036
- Co-author: Preimplantation Genetic Testing of Aneuploidy by Next Generation Sequencing: Association of Maternal Age and Chromosomal Abnormalities of Blastocyst, Open Access Macedonian Journal of Medical Sciences. 2019; 7(24): 4427–4431.
- Co-author: Short Tandem Repeats Used in Preimplantation Genetic Testing of Β-Thalassemia: Genetic Polymorphisms For 15 Linked Loci in the Vietnamese Population, Open Access Macedonian Journal of Medical Sciences. 2019; 7(24):4383-4388.